Exposition to Biological Control Agent Trichoderma stromaticum Increases the Development of Cancer in Mice Injected With Murine Melanoma.
Identifieur interne : 000151 ( Main/Exploration ); précédent : 000150; suivant : 000152Exposition to Biological Control Agent Trichoderma stromaticum Increases the Development of Cancer in Mice Injected With Murine Melanoma.
Auteurs : Uener R. Dos Santos [Brésil] ; Marliete C. Costa [Brésil] ; Gustavo J C. De Freitas [Brésil] ; Flávia S. De Oliveira [Brésil] ; Bianca R. Santos [Brésil] ; Juneo F. Silva [Brésil] ; Daniel A. Santos [Brésil] ; Adriana A M. Dias [Brésil] ; Luciana D. De Carvalho [Brésil] ; Danillo G. Augusto [Brésil] ; Jane L. Dos Santos [Brésil]Source :
- Frontiers in cellular and infection microbiology [ 2235-2988 ] ; 2020.
Abstract
Biological control agents (BCA) are an alternative to chemical pesticides and an emerging strategy to safely eliminate plant pathogens. Trichoderma spp. are the most common fungi used as BCAs. They produce spores that are released into the air and can potentially interact with immune system of mammals. We previously showed that Trichoderma affects expression of genes encoding pattern recognition receptors (PRRs) and cytokines in mice. PRRs are involved in the recognition of microorganisms and can lead to pro-tumoral signaling. Here, we evaluated if mice injected with low doses of murine melanoma exhibited increased development of lung tumor when treated with conidia of T. stromaticum. Mice treated with T. stromaticum and inoculated with B16-F10 melanoma cells exhibited significant increase in tumor uptake (p = 0.006) and increased number of visible nodules in the lungs (p = 0.015). We also analyzed mRNA expression levels of genes encoding PRRs in lung of mice exposed to T. stromaticum and demonstrated that mice treated with T. stromaticum conidia exhibited lower expression levels of Clec7a and increased expression of Tlr4 (toll like receptor 4) compared to non-treated controls. The expression levels of Clec7a and Tlr2 were increased in mice treated with T. stromaticum and inoculated with murine melanoma compared to controls only inoculated with melanoma. Our results demonstrate that intranasal exposition to T. stromaticum increases tumor in the B16-F10 model, which may raise concerns regarding the safety of its use in agriculture.
DOI: 10.3389/fcimb.2020.00252
PubMed: 32547964
PubMed Central: PMC7272596
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Dos Santos</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus</wicri:regionArea><wicri:noRegion>Ilhéus</wicri:noRegion></affiliation></author><author><name sortKey="Costa, Marliete C" sort="Costa, Marliete C" uniqKey="Costa M" first="Marliete C" last="Costa">Marliete C. Costa</name><affiliation wicri:level="4"><nlm:affiliation>Departamento de Microbiologia, ICB - Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Departamento de Microbiologia, ICB - Universidade Federal de Minas Gerais, Belo Horizonte</wicri:regionArea><placeName><settlement type="city">Belo Horizonte</settlement><region type="state">Minas Gerais</region></placeName><orgName type="university">Université fédérale du Minas Gerais</orgName></affiliation></author><author><name sortKey="De Freitas, Gustavo J C" sort="De Freitas, Gustavo J C" uniqKey="De Freitas G" first="Gustavo J C" last="De Freitas">Gustavo J C. De Freitas</name><affiliation wicri:level="4"><nlm:affiliation>Departamento de Microbiologia, ICB - Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Departamento de Microbiologia, ICB - Universidade Federal de Minas Gerais, Belo Horizonte</wicri:regionArea><placeName><settlement type="city">Belo Horizonte</settlement><region type="state">Minas Gerais</region></placeName><orgName type="university">Université fédérale du Minas Gerais</orgName></affiliation></author><author><name sortKey="De Oliveira, Flavia S" sort="De Oliveira, Flavia S" uniqKey="De Oliveira F" first="Flávia S" last="De Oliveira">Flávia S. De Oliveira</name><affiliation wicri:level="4"><nlm:affiliation>Departamento de Genética, Ecologia e Evolução - ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Departamento de Genética, Ecologia e Evolução - ICB, Universidade Federal de Minas Gerais, Belo Horizonte</wicri:regionArea><placeName><settlement type="city">Belo Horizonte</settlement><region type="state">Minas Gerais</region></placeName><orgName type="university">Université fédérale du Minas Gerais</orgName></affiliation></author><author><name sortKey="Santos, Bianca R" sort="Santos, Bianca R" uniqKey="Santos B" first="Bianca R" last="Santos">Bianca R. Santos</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus</wicri:regionArea><wicri:noRegion>Ilhéus</wicri:noRegion></affiliation></author><author><name sortKey="Silva, Juneo F" sort="Silva, Juneo F" uniqKey="Silva J" first="Juneo F" last="Silva">Juneo F. Silva</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus</wicri:regionArea><wicri:noRegion>Ilhéus</wicri:noRegion></affiliation></author><author><name sortKey="Santos, Daniel A" sort="Santos, Daniel A" uniqKey="Santos D" first="Daniel A" last="Santos">Daniel A. Santos</name><affiliation wicri:level="4"><nlm:affiliation>Departamento de Microbiologia, ICB - Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Departamento de Microbiologia, ICB - Universidade Federal de Minas Gerais, Belo Horizonte</wicri:regionArea><placeName><settlement type="city">Belo Horizonte</settlement><region type="state">Minas Gerais</region></placeName><orgName type="university">Université fédérale du Minas Gerais</orgName></affiliation></author><author><name sortKey="Dias, Adriana A M" sort="Dias, Adriana A M" uniqKey="Dias A" first="Adriana A M" last="Dias">Adriana A M. Dias</name><affiliation wicri:level="4"><nlm:affiliation>Departamento de Genética, Ecologia e Evolução - ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Departamento de Genética, Ecologia e Evolução - ICB, Universidade Federal de Minas Gerais, Belo Horizonte</wicri:regionArea><placeName><settlement type="city">Belo Horizonte</settlement><region type="state">Minas Gerais</region></placeName><orgName type="university">Université fédérale du Minas Gerais</orgName></affiliation></author><author><name sortKey="De Carvalho, Luciana D" sort="De Carvalho, Luciana D" uniqKey="De Carvalho L" first="Luciana D" last="De Carvalho">Luciana D. De Carvalho</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus</wicri:regionArea><wicri:noRegion>Ilhéus</wicri:noRegion></affiliation></author><author><name sortKey="Augusto, Danillo G" sort="Augusto, Danillo G" uniqKey="Augusto D" first="Danillo G" last="Augusto">Danillo G. Augusto</name><affiliation wicri:level="1"><nlm:affiliation>Programa de Pós-Graduação em Genética, Universidade Federal Do Paraná, Curitiba, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Genética, Universidade Federal Do Paraná, Curitiba</wicri:regionArea><wicri:noRegion>Curitiba</wicri:noRegion></affiliation></author><author><name sortKey="Dos Santos, Jane L" sort="Dos Santos, Jane L" uniqKey="Dos Santos J" first="Jane L" last="Dos Santos">Jane L. Dos Santos</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus</wicri:regionArea><wicri:noRegion>Ilhéus</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in cellular and infection microbiology</title><idno type="eISSN">2235-2988</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Biological control agents (BCA) are an alternative to chemical pesticides and an emerging strategy to safely eliminate plant pathogens. <i>Trichoderma</i> spp. are the most common fungi used as BCAs. They produce spores that are released into the air and can potentially interact with immune system of mammals. We previously showed that <i>Trichoderma</i> affects expression of genes encoding pattern recognition receptors (PRRs) and cytokines in mice. PRRs are involved in the recognition of microorganisms and can lead to pro-tumoral signaling. Here, we evaluated if mice injected with low doses of murine melanoma exhibited increased development of lung tumor when treated with conidia of <i>T. stromaticum</i>. Mice treated with <i>T. stromaticum</i> and inoculated with B16-F10 melanoma cells exhibited significant increase in tumor uptake (<i>p</i> = 0.006) and increased number of visible nodules in the lungs (<i>p</i> = 0.015). We also analyzed mRNA expression levels of genes encoding PRRs in lung of mice exposed to <i>T. stromaticum</i> and demonstrated that mice treated with <i>T. stromaticum</i> conidia exhibited lower expression levels of <i>Clec7a</i> and increased expression of <i>Tlr4</i> (toll like receptor 4) compared to non-treated controls. The expression levels of <i>Clec7a</i> and <i>Tlr2</i> were increased in mice treated with <i>T. stromaticum</i> and inoculated with murine melanoma compared to controls only inoculated with melanoma. Our results demonstrate that intranasal exposition to <i>T. stromaticum</i> increases tumor in the B16-F10 model, which may raise concerns regarding the safety of its use in agriculture.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">32547964</PMID><DateRevised><Year>2020</Year><Month>06</Month><Day>19</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">2235-2988</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Frontiers in cellular and infection microbiology</Title><ISOAbbreviation>Front Cell Infect Microbiol</ISOAbbreviation></Journal><ArticleTitle>Exposition to Biological Control Agent <i>Trichoderma stromaticum</i> Increases the Development of Cancer in Mice Injected With Murine Melanoma.</ArticleTitle><Pagination><MedlinePgn>252</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fcimb.2020.00252</ELocationID><Abstract><AbstractText>Biological control agents (BCA) are an alternative to chemical pesticides and an emerging strategy to safely eliminate plant pathogens. <i>Trichoderma</i> spp. are the most common fungi used as BCAs. They produce spores that are released into the air and can potentially interact with immune system of mammals. We previously showed that <i>Trichoderma</i> affects expression of genes encoding pattern recognition receptors (PRRs) and cytokines in mice. PRRs are involved in the recognition of microorganisms and can lead to pro-tumoral signaling. Here, we evaluated if mice injected with low doses of murine melanoma exhibited increased development of lung tumor when treated with conidia of <i>T. stromaticum</i>. Mice treated with <i>T. stromaticum</i> and inoculated with B16-F10 melanoma cells exhibited significant increase in tumor uptake (<i>p</i> = 0.006) and increased number of visible nodules in the lungs (<i>p</i> = 0.015). We also analyzed mRNA expression levels of genes encoding PRRs in lung of mice exposed to <i>T. stromaticum</i> and demonstrated that mice treated with <i>T. stromaticum</i> conidia exhibited lower expression levels of <i>Clec7a</i> and increased expression of <i>Tlr4</i> (toll like receptor 4) compared to non-treated controls. The expression levels of <i>Clec7a</i> and <i>Tlr2</i> were increased in mice treated with <i>T. stromaticum</i> and inoculated with murine melanoma compared to controls only inoculated with melanoma. Our results demonstrate that intranasal exposition to <i>T. stromaticum</i> increases tumor in the B16-F10 model, which may raise concerns regarding the safety of its use in agriculture.</AbstractText><CopyrightInformation>Copyright © 2020 Santos, Costa, de Freitas, de Oliveira, Santos, Silva, Santos, Dias, de Carvalho, Augusto and dos Santos.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dos Santos</LastName><ForeName>Uener R</ForeName><Initials>UR</Initials><AffiliationInfo><Affiliation>Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Costa</LastName><ForeName>Marliete C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Departamento de Microbiologia, ICB - Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Freitas</LastName><ForeName>Gustavo J C</ForeName><Initials>GJC</Initials><AffiliationInfo><Affiliation>Departamento de Microbiologia, ICB - Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Oliveira</LastName><ForeName>Flávia S</ForeName><Initials>FS</Initials><AffiliationInfo><Affiliation>Departamento de Genética, Ecologia e Evolução - ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Santos</LastName><ForeName>Bianca R</ForeName><Initials>BR</Initials><AffiliationInfo><Affiliation>Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silva</LastName><ForeName>Juneo F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Santos</LastName><ForeName>Daniel A</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>Departamento de Microbiologia, ICB - Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dias</LastName><ForeName>Adriana A M</ForeName><Initials>AAM</Initials><AffiliationInfo><Affiliation>Departamento de Genética, Ecologia e Evolução - ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Carvalho</LastName><ForeName>Luciana D</ForeName><Initials>LD</Initials><AffiliationInfo><Affiliation>Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Augusto</LastName><ForeName>Danillo G</ForeName><Initials>DG</Initials><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Genética, Universidade Federal Do Paraná, Curitiba, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dos Santos</LastName><ForeName>Jane L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Brazil.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Cell Infect Microbiol</MedlineTA><NlmUniqueID>101585359</NlmUniqueID><ISSNLinking>2235-2988</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Trichoderma</Keyword><Keyword MajorTopicYN="N">Tricovab</Keyword><Keyword MajorTopicYN="N">biological control</Keyword><Keyword MajorTopicYN="N">cancer</Keyword><Keyword MajorTopicYN="N">metastasis</Keyword><Keyword MajorTopicYN="N">patter recognition receptor</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>01</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>04</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>6</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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